Ms Smith Visit 1: 32-year-old sensitized woman with a potential living kidney donor inquiring about transplant options

Curriculum:
Overcoming Obstacles for Sensitized Kidney Recipients
Credits:
1 CA-BRN 1 CEPTC 1 AMA PRA Category 1 Credit(s)™
Launch Date:
19-Feb-14
Expiration Date:
The accreditation for this activity has expired.

Primary Audience:

No primary audience was provided.

Relevant Terms:

No primary audience was provided.

Jayme E. Locke, MD, MPH

Jayme E. Locke, MD, MPH
Assistant Professor of Surgery
Division of Transplantation
Director, Incompatible Kidney Transplant and Kidney Paired Donation Programs
University of Alabama at Birmingham
Birmingham, AL

Jayme E. Locke, MD, MPH, is an Assistant Professor of Surgery at the University of Alabama at Birmingham where she also serves as Director of the Incompatible Kidney Transplant and Kidney Paired Donation Programs. She received her medical degree from the Brody School of Medicine at East Carolina University in Greenville, North Carolina. She completed a residency in general surgery and a fellowship in abdominal transplant surgery at The Johns Hopkins Hospital in Baltimore, Maryland. Dr Locke also completed a Master of Public Health degree with an emphasis in biostatistics and epidemiology at The Johns Hopkins Bloomberg School of Public Health.
 
As an abdominal transplant surgeon, Dr Locke specializes in innovative strategies for the transplantation of incompatible organs, disparities in access to and outcomes after solid organ transplantation, and transplantation of HIV-infected end-stage patients. Her research interests include complex statistical analysis and modeling of transplant outcomes and behavioral research focused on health disparities. She has authored 37 articles in peer-reviewed journals and 11 book chapters and has presented 32 abstracts on these topics. In addition, Dr Locke is a reviewer for several journals, including Archives of Surgery, American Journal of Transplantation, American Journal of Kidney Diseases, and Liver Transplantation. She is also a member of the American Society of Transplantation (AST), American Society of Transplant Surgeons (ASTS), and American Society of Nephrology (ASN), as well as a candidate for the American College of Surgeons (ACS). She currently serves as a Kidney-Pancreas Committee Member and on the Pediatric-Adult Transition Work Group of the AST. Dr Locke is the recipient of numerous honors and has most recently received the ASTS 2013 Winter Symposium Top Ten Abstract Award and ATC 2013 Young Investigator Award.

Robert A. Montgomery, MD, DPhil, FACS

Robert A. Montgomery, MD, DPhil, FACS
Professor of Surgery
Director, Incompatible Kidney Transplant Program
Chief, Division of Transplantation
Director, Comprehensive Transplant Center
Johns Hopkins University and Hospital
Baltimore, MD

Robert A. Montgomery, MD, DPhil, FACS, is Professor of Surgery, Director, Incompatible Kidney Transplant Program, Chief, Division of Transplantation, and Director, Comprehensive Transplant Center at The Johns Hopkins University and Hospital in Baltimore, Maryland. He is also the inaugural recipient of the Margery K. and Thomas Pozefsky Professorship in Kidney Transplantation. He received his Doctor of Medicine with Honors from the University of Rochester School of Medicine in New York. He received his Doctor of Philosophy from Balliol College, The University of Oxford, England in molecular immunology. Dr Montgomery completed his general surgical training, multi-organ transplantation fellowship, and postdoctoral fellowship in human molecular genetics at The Johns Hopkins University and Hospital.
 
Dr Montgomery has been involved in the development of innovative approaches to expand live donor renal transplantation including: the laparoscopic donor nephrectomy, positive crossmatch and ABO-incompatible transplantation, paired kidney exchange, and altruistic donor programs. His work with patients in these programs has been featured in numerous documentaries, The Today Show, Good Morning America, the CBS and NBC Evening News, CNN, and The Discovery Channel, and in print in USA Today, The New York Times, The Washington Post, and The Wall Street Journal. He was part of the team that developed the laparoscopic procedure for live kidney donation. He led the team that performed the first triple swap, triple domino swap, and the world's first quintuple kidney paired donation. He is considered a world expert on kidney transplantation for highly sensitized and ABO-incompatible patients and has led several national task forces and consensus groups on this subject. His other clinical interests include the use of expanded criteria donors and pulsatile perfusion pumping to preserve and rescue organs that were not previously used for transplantation. Dr Montgomery has been the principal investigator on several extramural and NIH grants for the basic science study of the mechanisms underlying the immunomodulatory effect of plasmapheresis and incompatible transplantation, as well as gene and cell-based therapies in solid organ transplantation. In addition, Dr Montgomery is a fellow of the American College of Surgeons and a member of many surgical societies. He has received many awards and distinctions including multiple scholarships from the American College of Surgeons and the American Society of Transplant Surgeons.

Dorry L. Segev, MD, PhD

Dorry L. Segev, MD, PhD
Associate Professor of Surgery
Johns Hopkins University School of Medicine
Associate Professor of Epidemiology and Biostatistics
Johns Hopkins University School of Public Health
Baltimore, MD

Dorry L. Segev, MD, PhD, is Associate Professor of Surgery at Johns Hopkins University School of Medicine and Associate Professor of Epidemiology and Biostatistics at Johns Hopkins University School of Public Health in Baltimore, Maryland. He is also Chair of the Mentorship Committee in the Department of Surgery. Dr Segev received his MD, an MHS in biostatistics, and a PhD in clinical investigation and completed his general surgery residency and transplant surgery fellowship at Johns Hopkins University.
 
Dr Segev is an abdominal transplant surgeon focusing on minimally invasive live donor surgery and incompatible organ transplantation. His research uses advanced statistical methods for mathematical modeling and simulation of medical data, analysis of large healthcare datasets, and outcomes research. He has made significant contributions to the field of transplantation including the development of a mathematical model to facilitate a nationwide Kidney Paired Donation program in both the United States and Canada. He is an NIH Clinical Research Scholar, an American Geriatrics Society Dennis W. Jahnigen Scholar, a National Institute of Aging Paul Beeson Scholar, a senior investigator for the Scientific Registry of Transplant Recipients, and a recipient of the Doris Duke Clinical Scientist Development Award for his groundbreaking work in clinical decision-making for renal failure patients over 65.
 
Dr Segev has authored more than 150 peer-reviewed research articles in journals such as The New England Journal of Medicine, the Journal of the American Medical Association, the American Journal of Transplantation, Annals of Surgery, and the Journal of the American Society of Nephrology. He is an Associate Editor for the American Journal of Transplantation, the American Journal of Kidney Diseases, and Liver Transplantation. His work is regularly featured in widely read media including TIME magazine, the Discovery Channel, U.S. News & World Report, and The New York Times.
1. Describe how kidney paired donation and desensitization can be used to increase kidney transplant rates for HLA-incompatible individuals
2. Summarize the short- and long-term recipient outcomes data for desensitization protocols in kidney transplant recipients
3. Implement strategies involving desensitization and/or kidney paired donation to improve transplant rates for HLA-incompatible individuals