Considering Rare Causes of Acute Abdominal Pain: A Diagnostic Challenge

Emergency Medicine
Considering Rare Causes of Acute Abdominal Pain: A Diagnostic Challenge
1.0 AMA PRA Category 1 Credit(s)
Launch Date:
March 31, 2020
Expiration Date:
The accreditation for this activity has expired.

Primary Audience:

Emergency Medicine clinicians, Primary Care clinicians, Gastroenterologists

Relevant Terms:

Acute hepatic porphyria, porphyria

Herbert L. Bonkovsky, MD

Professor of Medicine and Molecular Medicine and Translational Science
Director of Laboratory for Liver & Metabolic Disorders
Wake Forest University School of Medicine/NC Baptist Hospital
Winston-Salem, North Carolina

Herbert L. Bonkovsky, MD, is a tenured Professor of Medicine and Molecular Medicine & Translational Research and Director of Hepatology/Liver Service Line and The Liver and Metabolic Disorders Laboratory at Wake Forest University/NC Baptist Medical Center, Winston-Salem, NC. Dr. Bonkovsky also has academic appointments as Visiting Professor at Winston-Salem State University, Professor of Medicine at The University of CT Health Center, and Professor of Biology and Medicine at the University of North Carolina.

Dr. Bonkovsky is known nationally and internationally as a clinical hepatologist, teacher, mentor, and clinical investigator. Dr. Bonkovsky has continued to maintain an active clinical practice, focused on liver disorders and metabolic disorders, especially disorders of iron, porphyrin, and heme metabolism. His currently funded research is in porphyrin and heme metabolism, effects of heme and iron on gene expression and intermediary metabolism, and drug- and herbal supplement-induced liver injury.

1. Recognize the most common neurovisceral signs and symptoms of porphyria and how these can be overlooked or confused with other conditions
2. Identify the recommended laboratory tests that can help establish a diagnosis of porphyria
3. Describe the role of genetic testing that can pinpoint the type of porphyria

Information on this Educational Activity

Clinical Care Options, LLC (CCO) requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any relevant conflict of interest (COI) they may have as related to the content of this activity. All identified COI are thoroughly vetted and resolved according to CCO policy. CCO is committed to providing its learners with high-quality CME/CE activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of a commercial interest.

The faculty reported the following financial relationships or relationships to products or devices they or their spouse/life partner have with commercial interests related to the content of this CME/CE activity:



Herbert L. Bonkovsky, MD, has disclosed that he received consulting fees from Recordati Rare Chemicals and funds for research support from Alnylam, Gilead Sciences, and Mitsubishi Tanabe.



Zachary Schwartz, MSc, ELS

Scientific Director

Zachary Schwartz, MSc, ELS, has no relevant conflicts of interest to report.


Anne Roc, PhD

Director, Scientific Services

Anne Roc, PhD, has no relevant conflicts of interest to report.


Wendy Gloffke, PhD

Medical Writer

Wendy Gloffke, PhD, has no relevant conflicts of interest to report.


Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.



Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.


Target Audience

This program is primarily intended for gastroenterologists, emergency medicine specialists, primary care practitioners and other clinicians who may see patients with abdominal symptoms related to porphyria.



The goal of this activity is to improve the competence of learners in considering rare causes of acute abdominal pain and to perform appropriate diagnostic tests in a timely manner to establish the correct diagnosis.



Joint Accreditation Statement

In support of improving patient care, Clinical Care Options, LLC (CCO) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.


Physician Continuing Medical Education

Credit Designation

CCO designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.


Program Medium

This program has been made available online.



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